Half Life Extensions

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2018;24(41):4932-4946. doi: 10.2174/1381612825666190206105232. Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins. Short half-lives resulting from sensitivity to proteases and rapid renal clearance mean that peptide drugs tend to require frequent doses. Several peptide . Strategies for half-life extension are often required in the design of new biopharmaceuticals. This Viewpoint focuses on chemical moieties that . The long serum half-life of albumin is achieved in part by its size, 66 kDa, which prevents clearance through the kidney, and by its interaction with the neonatal Fc . An approach for half-life extension and activity preservation of an anti-diabetic peptide drug based on genetic fusion with an albumin-binding . As described previously, due in part to its size, being above the renal threshold and by its specific interaction and recycling by FcRn, albumin has a peculiarly long . For this reason, the pharmaceutical and biotech sectors are paying increasing attention to half-life extension strategies, with a number of research institutes and . Pages dans la catégorie « Extension de Half-Life ». Cette catégorie contient les 7 pages suivantes. Outils : Arborescence · Graphique · Décompte · Recherche . The impact of each half‐life extension method is illustrated through selected examples. Table 1. Currently approved peptide‐ and protein‐based .

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